- Molecular NameVenlafaxine
- SynonymVenlafaxina [INN-Spanish]; Venlafaxine [INN:Ban]; Venlafaxinum [INN-Latin]
- Weight277.408
- Drugbank_IDDB00285
- ACS_NO93413-69-5
- Show 3D model
- LogP (experiment)0.43
- LogP (predicted, AB/LogP v2.0)3.57
- pkaN/A
- LogD (pH=7, predicted)2.13
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-0.21
- LogSw (predicted, AB/LogsW2.0)0.54
- Sw (mg/ml) (predicted, ACD/Labs)1.49
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds5
- TPSA32.7
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI)
- Absorption_value95.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability27.5
- Protein binding27.0
- Volume of distribution (VD)7.5 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIts equipotent O-desmethyl metabolite (formation catalyzed by CYP2D6-polymorphic).
- Half life4.9 h; O-desmethylvenlafaxine 10.3 h.
- ExcretionRenal
- Urinary Excretion4.6
- Clerance22 ml/min/kg
- ToxicityMost patients overdosing with venlafaxine develop only mild symptoms. However, severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. Venlafaxine's toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following large doses.
- LD50 (rat)N/A
- LD50 (mouse)N/A