- Molecular NameEtidocaine
- SynonymNA
- Weight276.424
- Drugbank_IDN/A
- ACS_NO36637-18-0
- Show 3D model
- LogP (experiment)3.7
- LogP (predicted, AB/LogP v2.0)2.8
- pka7.9
- LogD (pH=7, predicted)1.85
- Solubility (experiment)0.143 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.52
- LogSw (predicted, AB/LogsW2.0)0.93
- Sw (mg/ml) (predicted, ACD/Labs)0.18
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds7
- TPSA32.34
- StatusN/A
- AdministrationParenteral
- PharmacologyA local anesthetic given by injection during surgical procedures and labor and delivery.
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed into the circulation after epidural administration.
- Caco_2N/A
- Bioavailability0.0
- Protein binding94.0
- Volume of distribution (VD)2 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, 1.7.
- MetabollsmExtensively metabolised by N-dealkylation, hydrolysis and ring hydroxylation. Desethyletidocaine and despropyletidocaine are detectable in plasma.
- Half life2.5 h (After intravenous administration), increased to about 6 h after epidural administration.
- ExcretionLess than 1% of a dose is excreted in the urine unchanged in 48 h.
- Urinary ExcretionN/A
- Clerance15 ml/min/kg
- ToxicityPlasma concentrations greater than 2 mg/L may be associated with toxic effects.
- LD50 (rat)N/A
- LD50 (mouse)LD50=56 (intraperitoneal); LD50=7 (intravenous)