• Molecular NameChlorpheniramine
  • SynonymChloropheniramine; Chlorophenylpyridamin; Chlorophenylpyridamine; Chloroprophenpyridamine; Chlorphenamine; Chlorpheniramine Maleate; Chlorprophenpyridamine; Clorfeniramina; Dexchlorpheniramine; Dexchlorpheniramine Maleate
  • Weight275.783
  • Drugbank_IDDB01114
  • ACS_NO132-22-9
  • Show 2D model
  • LogP (experiment)3.39
  • LogP (predicted, AB/LogP v2.0)3.28
  • pka9.2
  • LogD (pH=7, predicted)1.91
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.56
  • LogSw (predicted, AB/LogsW2.0)0.32
  • Sw (mg/ml) (predicted, ACD/Labs)0.06
  • No.of HBond Donors0
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds5
  • TPSA19.37
  • StatusFDA approved
  • AdministrationOral, IV, IM, SC
  • PharmacologyA first-generation alkylamine antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. Its sedative effects are relatively weak compared to other first-generation antihistamines. Chlorpheniramine is one of the most commonly-used antihistamines in small-animal veterinary practice as well.
  • Absorption_value80.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability41.0
  • Protein binding70.0
  • Volume of distribution (VD)3.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (CYP2D6)
  • Half life20 h
  • ExcretionRenal
  • Urinary Excretion0.3~26
  • Clerance1.7 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A