- Molecular NameCarprofen
- Synonym2-(6-Chloro-9H-carbazol-2-yl)propanoic acid; 6-Chloro-alpha-methyl-9H-carbazole-2-acetic acid; 6-Chloro-alpha-methylcarbazole-2-acetic acid; Carprofene [inn-french]; Carprofeno [inn-spanish]; Carprofenum [inn-latin]
- Weight273.719
- Drugbank_IDDB00821
- ACS_NO53716-49-7
- Show 2D model
- LogP (experiment)4.293
- LogP (predicted, AB/LogP v2.0)4.56
- pka9.2
- LogD (pH=7, predicted)1.85
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-3.16
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors2
- No.of HBond Acceptors3
- No.of Rotatable Bonds2
- TPSA53.09
- StatusFDA approved
- AdministrationN/A
- PharmacologyA non-steroidal anti-inflammatory drug that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. It can be used both short term, for joint pain or post-operative inflammation, or for day-to-day relief from the pain and inflammation associated with osteoarthritis, hip dysplasia, and other forms of joint deterioration .
- Absorption_value100.0
- Absorption (description)Rapidly and nearly completely absorbed (more than 90% bioavailable) when administered orally.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding99.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmCarprofen is metabolized in liver to beta-D-glucuronoside by UGT1A3, UGT1A6, UGT2B7.
- Half life8 h (4.5~9.8 h) in dogs.
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of NSAID overdose include dizziness and nystagmus.
- LD50 (rat) 282 mg/kg
- LD50 (mouse)149 mg/kg