- Molecular NameEstradiol
- Synonym17-beta; Beta-Estradiol; Cis-Estradiol; Cis-Oestradiol; D-Estradiol; D-Oestradiol; Dihydrofollicular Hormone; Dihydrofolliculin; Dihydroxyesterin; Dihydroxyestrin; Dihydroxyoestrin; estradiol; Estradiol Cypionate; Estradiol Valerate; Estradiol-17beta
- Weight272.388
- Drugbank_IDDB00783
- ACS_NO50-28-2
- Show 3D model
- LogP (experiment)4.01
- LogP (predicted, AB/LogP v2.0)3.36
- pka10.4
- LogD (pH=7, predicted)3.36
- Solubility (experiment)0.0036 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-4.95
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors2
- No.of HBond Acceptors2
- No.of Rotatable Bonds0
- TPSA40.46
- StatusFDA approved
- AdministrationOral, transdermal
- PharmacologyA sex hormone.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability43.0
- Protein binding95.0
- Volume of distribution (VD)1.2
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmExogenous estrogens are metabolized using the same mechanism as endogenous estrogens. Estrogens are partially metabolized by cytochrome P450.
- Half life36 h
- ExcretionUrine
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityCan cause nausea and vomiting, and withdrawal bleeding may occur in females.
- LD50 (rat)N/A
- LD50 (mouse)N/A