• Molecular NameDextromethorphan
  • SynonymD-Methorphan; D-Methorphan Hydrobromide; Delta-Methorphan; Demorphan; Demorphan Hydrobromide; Demorphine; Destrometerfano [Dcit]; Dextromethorfan [Czech]; Dextromethorphan Bromhydrate; Dextromethorphan Bromide; Dextrometorfano [INN-Spanish]; Dextrometorphan; Dextromorphan; Dexyromethorphan; L-Methorphan; Levomethorphan; Levomethorphan [Ban:Dcf:Inn]; Levomethorphane [INN-French]; Levomethorphanum [INN-Latin]; Levometorfano [INN-Spanish]
  • Weight271.404
  • Drugbank_IDDB00514
  • ACS_NO125-71-3
  • Show 3D model
  • LogP (experiment)4.323
  • LogP (predicted, AB/LogP v2.0)3.5
  • pka8.3
  • LogD (pH=7, predicted)1.86
  • Solubility (experiment)0.0747 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.13
  • LogSw (predicted, AB/LogsW2.0)0.12
  • Sw (mg/ml) (predicted, ACD/Labs)0.19
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds1
  • TPSA12.47
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antitussive drug. It is one of the active ingredients used to prevent coughs in many over-the-counter cold and cough medicines. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychological applications.
  • Absorption_valueN/A
  • Absorption (description)Well absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability11.0
  • Protein bindingN/A
  • Volume of distribution (VD)255~316 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (liver) enzymes: major CYP2D6, minor CYP3A4, and minor CYP3A5. Metabolised by N- and O-demethylation followed by sulfate or glucuronic acid conjugation; O-demethylation involves the cytochrome P450 isoenzyme CYP2D6. The major metabolite is dextrorphan, (+)-3-hydroxy-N-methylmorphinan which has some activity; (+)-3-hydroxymorphinan has also been identified.
  • Half life3.2~3.6 h in rapid metabolisers.
  • ExcretionAbout 50% of a dose is excreted in the urine in 24 h, mostly as the glucuronide and sulfate conjugates of the metabolites; about 8% of a dose is excreted as unchanged drug in 6 h.
  • Urinary Excretion0.19
  • CleranceN/A
  • ToxicityThe most frequent adverse reactions to Brompheniramine Maleate, Dextromethorphan HBr and Phenylpropanolamine HCl Liquid include sedation, dryness of the mouth, nose and throat, thickening of bronchial secretions, and dizziness.
  • LD50 (rat)LD50=234
  • LD50 (mouse)LD50=234