- Molecular NameMedazepam
- SynonymNA
- Weight270.763
- Drugbank_IDN/A
- ACS_NO2898-12-6
- Show 2D model
- LogP (experiment)4.41
- LogP (predicted, AB/LogP v2.0)4.33
- pka6.2
- LogD (pH=7, predicted)4.26
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-4.12
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.02
- No.of HBond Donors0
- No.of HBond Acceptors2
- No.of Rotatable Bonds1
- TPSA15.6
- StatusN/A
- AdministrationPlasma : whole blood ratio, 1.9.
- PharmacologyA drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding100.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe active metabolites desmethyldiazepam (nordazepam) and diazepam may be detected in the blood shortly after dosing; desmethyldiazepam accumulates during chronic treatment. Desmethylmedazepam has also been detected in plasma.
- Half lifemedazepam 1~2 h, desmethyldiazepam about 40~100 h, but there is considerable intersubject variation
- ExcretionA total of up to about 75% of a dose is excreted in the urine and about 20% is eliminated in the faeces. The major urinary metabolite is oxazepam glucuronide, 2 to 3% of a dose being excreted in this form in 72 h; other urinary metabolites include desmethyldiazepam and temazepam.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)LD50=1.42 (po)
- LD50 (mouse)LD50=5.24 (peroral)