• Molecular NameNordazepam
  • Synonymdesoxydemoxepam; nordiazepam; desmethyldiazepam
  • Weight270.719
  • Drugbank_IDN/A
  • ACS_NO1088-11-5
  • Show 3D model
  • LogP (experiment)2.9
  • LogP (predicted, AB/LogP v2.0)2.85
  • pkaN/A
  • LogD (pH=7, predicted)2.85
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-3.79
  • LogSw (predicted, AB/LogsW2.0)0.03
  • Sw (mg/ml) (predicted, ACD/Labs)0.04
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds1
  • TPSA41.46
  • StatusN/A
  • AdministrationN/A
  • PharmacologyIt has anticonvulsant, anxiolytic, muscle relaxant and sedative properties. However, it is used primarily in the treatment of anxiety. It is an active metabolite of diazepam, chlordiazepoxide, clorazepate, prazepam, and medazepam.[
  • Absorption_value99.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability99.0
  • Protein binding97.0
  • Volume of distribution (VD)0.5 to 2.5 L/kg, increased in elderly subjects.
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life36~200 h
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A