- Molecular NameTolbutamide
- SynonymNA
- Weight270.353
- Drugbank_IDDB01124
- ACS_NO64-77-7
- Show 3D model
- LogP (experiment)2.34
- LogP (predicted, AB/LogP v2.0)2.21
- pka5.3
- LogD (pH=7, predicted)0.41
- Solubility (experiment)0.109 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.08
- LogSw (predicted, AB/LogsW2.0)0.19
- Sw (mg/ml) (predicted, ACD/Labs)0.42
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds5
- TPSA83.65
- StatusFDA approved
- AdministrationN/A
- PharmacologyA first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug sold under the brand name Orinase. This drug may be used in the management of type II diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas.
- Absorption_value90.0
- Absorption (description)Well absorbed. Absorption is unaltered if taken with food but is increased with high pH.
- Caco_2N/A
- Bioavailability85.0
- Protein binding93.5
- Volume of distribution (VD)0.12 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolized primarily by CYP2C9 (polymorphic).
- Half life5.9 h
- ExcretionRenal
- Urinary Excretion0.1
- Clerance0.22 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)LD50=2600 mg/kg