- Molecular NameOrphenadrine
- SynonymMephenamine; O-Methyldiphenhydramine; Orphenadine; Orphenadrin; Orphenadrine Citrate; Orphenate; Orphenedrine
- Weight269.388
- Drugbank_IDDB01173
- ACS_NO83-98-7
- Show 3D model
- LogP (experiment)3.77
- LogP (predicted, AB/LogP v2.0)4.0
- pka8.4
- LogD (pH=7, predicted)2.31
- Solubility (experiment)Slightly soluble
- LogS (predicted, ACD/Labs)(ph=7)-1.44
- LogSw (predicted, AB/LogsW2.0)0.05
- Sw (mg/ml) (predicted, ACD/Labs)0.21
- No.of HBond Donors0
- No.of HBond Acceptors2
- No.of Rotatable Bonds6
- TPSA12.47
- StatusFDA approved
- AdministrationOral, intravenous, intramuscular
- PharmacologyAn anticholinergic drug of the ethanolamine antihistamine class with prominent CNS and peripheral actions used to treat painful muscle spasm and other symptoms and conditions as well as some aspects of Parkinson's Disease.
- Absorption_value100.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability90.0
- Protein binding95.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmBiotransformation occurs mainly in the liver. Pharmacologically active metabolites are N-demethyl orphenadrine and N,N-didemethyl orphenadrine.
- Half life14 h
- ExcretionRenal and biliary
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)LD50=255 mg/kg
- LD50 (mouse)LD50=100 mg/kg