• Molecular NameMetoprolol
  • SynonymMetoprolol succinate; Metoprolol Tartrate
  • Weight267.369
  • Drugbank_IDDB00264
  • ACS_NO37350-58-6
  • Show 3D model
  • LogP (experiment)1.88
  • LogP (predicted, AB/LogP v2.0)2.05
  • pka9.7
  • LogD (pH=7, predicted)-0.35
  • Solubility (experiment)16.9 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)0.57
  • LogSw (predicted, AB/LogsW2.0)10.29
  • Sw (mg/ml) (predicted, ACD/Labs)10.69
  • No.of HBond Donors2
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds9
  • TPSA50.72
  • StatusFDA approved
  • AdministrationOral, IV
  • PharmacologyA selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.
  • Absorption_value96.0
  • Absorption (description)N/A
  • Caco_2-4.59
  • Bioavailability38.0
  • Protein binding11.0
  • Volume of distribution (VD)4.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life3.2 h
  • ExcretionRenal
  • Urinary Excretion10
  • Clerance15 ml/min/kg
  • ToxicityToxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure.
  • LD50 (rat)LD50=5500 mg/kg
  • LD50 (mouse)LD50=2090