- Molecular NameTramadol
- Synonymtramadol; Tramadol HCl; Tramadol hydrochloride; Tramadolum [INN-Latin]; Tramodol Hcl
- Weight263.381
- Drugbank_IDDB00193
- ACS_NO27203-92-5
- Show 3D model
- LogP (experiment)3.01
- LogP (predicted, AB/LogP v2.0)2.65
- pka8.3, 9.41
- LogD (pH=7, predicted)0.46
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.49
- LogSw (predicted, AB/LogsW2.0)2.23
- Sw (mg/ml) (predicted, ACD/Labs)3.65
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds4
- TPSA32.7
- StatusFDA approved
- AdministrationOral, IV, IM, rectal, sublingual, buccal, intranasal
- PharmacologyA centrally acting analgesic, used for treating moderate to severe pain.
- Absorption_value95.0
- Absorption (description)Racemic tramadol is rapidly and almost completely absorbed after oral administration.
- Caco_2N/A
- Bioavailability72.5
- Protein binding20.0
- Volume of distribution (VD)2.7 L/kg; slightly higher in females compared with males (2.9 L/kg versus 2.6 L/kg)
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmTramadol (T) is metabolized by CYP2D6 to an active O-desmethyl-metabolite (M1); there are other CYP-catalyzed metabolites.
- Half life5.5 h
- ExcretionRenal
- Urinary Excretion10~30
- Clerance8 ml/min/kg
- ToxicityLD50=350mg/kg (orally in mice)
- LD50 (rat)N/A
- LD50 (mouse)N/A