• Molecular NameMethapyrilene
  • Synonym2-[[2-(Dimethylamino)ethyl]-2-thenylamino]pyridine; Methapyrilene HCL; Methapyrilene hydrochloride; Methapyriline; Methoxylene; Methypyrilene hydrochloride; N,N-Dimethyl-N'-pyrid-2-yl-N'-2-thenylethylenediamine
  • Weight261.393
  • Drugbank_IDN/A
  • ACS_NO91-80-5
  • Show 2D model
  • LogP (experiment)2.87
  • LogP (predicted, AB/LogP v2.0)2.91
  • pka3.7, 8.9
  • LogD (pH=7, predicted)1.12
  • Solubility (experiment)0.599 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.65
  • LogSw (predicted, AB/LogsW2.0)1.9
  • Sw (mg/ml) (predicted, ACD/Labs)0.42
  • No.of HBond Donors0
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds6
  • TPSA47.61
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA pyridine antihistamine which was developed in the early 1950s. It has relatively strong sedative effects, to the extent that its primary use was as a medication for insomnia rather than for its antihistamine action.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability20.0
  • Protein bindingN/A
  • Volume of distribution (VD)4 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life1~2 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A