• Molecular NameIfosfamide
  • SynonymAsta Z 4942; I-Phosphamide; Ifosfamid; Ifosfamide Sterile; Ifosphamide; Ifsofamide; Iphosphamid; Iphosphamide; Isofosfamide; Isophosphamide
  • Weight261.089
  • Drugbank_IDDB01181
  • ACS_NO3778-73-2
  • Show 3D model
  • LogP (experiment)0.86
  • LogP (predicted, AB/LogP v2.0)0.99
  • pkaN/A
  • LogD (pH=7, predicted)0.99
  • Solubility (experiment)3.78 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.81
  • LogSw (predicted, AB/LogsW2.0)89.82
  • Sw (mg/ml) (predicted, ACD/Labs)40.67
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds5
  • TPSA51.38
  • StatusFDA approved
  • Administrationintravenously
  • PharmacologyA nitrogen mustard alkylating agent used in the treatment of cancer.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability94.0
  • Protein binding0.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolic activation to 4-hydroxyifosfamide catalyzed by CYP3A and CYP2C.
  • Half life5.6 h (low dose: 1.5 g/m2) and 15.2 h (high dose: 5 g/m2)
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySide effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
  • LD50 (rat)LD50=150-190 mg/kg
  • LD50 (mouse)LD50=390-1005 mg/kg