• Molecular NameOxymetazoline
  • SynonymOximetazolinum; oxymetazoline hydrochloride crystalline; Oxymethazoline; Oxymetozoline
  • Weight260.381
  • Drugbank_IDDB00935
  • ACS_NO1491-59-4
  • Show 2D model
  • LogP (experiment)3.457
  • LogP (predicted, AB/LogP v2.0)2.96
  • pkaN/A
  • LogD (pH=7, predicted)0.02
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.02
  • LogSw (predicted, AB/LogsW2.0)0.34
  • Sw (mg/ml) (predicted, ACD/Labs)0.08
  • No.of HBond Donors2
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds3
  • TPSA44.62
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyOxymetazoline is available over-the-counter as a topical decongestant in the form of oxymetazoline hydrochloride in nasal sprays such as Afrin, Dristan, Vicks Sinex, and Mucinex Full Force. Oxymetazoline is also used to treat epistaxis and eye redness due to minor irritation (marketed as Visine L.R. in the form of eye drops).
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability11.0
  • Protein binding80.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life5~6 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A