• Molecular NameSuprofen
  • SynonymSuprofene [INN-French]; Suprofenum [INN-Latin]
  • Weight260.313
  • Drugbank_IDDB00870
  • ACS_NO40828-46-4
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.88
  • pka3.9
  • LogD (pH=7, predicted)0.0
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)-0.76
  • LogSw (predicted, AB/LogsW2.0)0.3
  • Sw (mg/ml) (predicted, ACD/Labs)0.12
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds4
  • TPSA82.61
  • StatusFDA approved; US withdrawn
  • AdministrationN/A
  • PharmacologyA topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability92.0
  • Protein binding99.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPrimarily hepatic (mainly via cytochrome P450 isozyme 2C9).
  • Half life2 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include bleeding in the eye or redness or swelling of the eye or the eyelid, blurred vision or other change in vision, fever or chills, itching or tearing, nausea or vomiting, pain, sensitivity to light, shortness of breath, sticky or matted eyelashes, swelling of face, throbbing pain, tightness in chest, troubled breathing, and wheezing.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A