- Molecular NameSalsalate
- Synonymsalicylsalicylic acid; Salsalatum [inn-latin]; Sasapyrine
- Weight258.229
- Drugbank_IDDB01399
- ACS_NO552-94-3
- Show 3D model
- LogP (experiment)3.4
- LogP (predicted, AB/LogP v2.0)3.48
- pka3.5, 9.8 (25°)
- LogD (pH=7, predicted)0.09
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-0.69
- LogSw (predicted, AB/LogsW2.0)0.15
- Sw (mg/ml) (predicted, ACD/Labs)0.15
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds4
- TPSA83.83
- StatusFDA approved
- AdministrationN/A
- PharmacologyA non-steroidal anti-inflammatory drug (NSAID). Salsalate is in a class of drugs called salicylates. Salsalate may work by inhibiting the production of and release of prostaglandins.
- Absorption_value100.0
- Absorption (description)Salsalate is insoluble in acid gastric fluids (< 0.1 mg/ml at pH 1.0), but readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged. The amount of salicylic acid available from salsalate is about 15% less than from aspirin, when the two drugs are administered on a salicylic acid molar equivalent basis (3.6 g salsalate/5 g aspirin). Food slows the absorption of all salicylates including salsalate.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmSalsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body.
- Half life1 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityDeath has followed ingestion of 10 to 30 g of salicylates in adults, but much larger amounts have been ingested without fatal outcome.
- LD50 (rat)N/A
- LD50 (mouse)N/A