• Molecular NameLevorphanol
  • SynonymDea No; 9220; Dea No; 9733; Levorfanol [INN-Spanish]; Levorfanolo [Dcit]; Levorphan; Levorphanal; Levorphanol Dl-Form; Levorphanol Tartrate; Levorphanolum [INN-Latin]; Methorfinan [Czech]; Methorphinan; Racemethorphanum; Racemorfano [INN-Spanish]
  • Weight257.377
  • Drugbank_IDDB00854
  • ACS_NO77-07-6
  • Show 2D model
  • LogP (experiment)3.11
  • LogP (predicted, AB/LogP v2.0)3.18
  • pka8.2
  • LogD (pH=7, predicted)1.53
  • Solubility (experiment)1.84 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.81
  • LogSw (predicted, AB/LogsW2.0)0.38
  • Sw (mg/ml) (predicted, ACD/Labs)0.9
  • No.of HBond Donors1
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds0
  • TPSA23.47
  • StatusFDA approved
  • Administrationoral, intravenous, intramuscular, subcutaneous
  • PharmacologyAn opioid medication used to treat severe pain.
  • Absorption_valueN/A
  • Absorption (description)Levorphanol is absorbed after oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding40.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmLevorphanol is extensively metabolized in the liver and is eliminated as the glucuronide metabolite.
  • Half life13 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityPostmortem concentrations in a 41-year-old female found dead after having ingested an unknown quantity of levorphanol were: blood 2.7 mg/L, bile 24 mg/L, brain 1.8 μg/g, kidney 3.4 μg/g, liver 5.4 μg/g, lung 17 μg/g, urine 2.3 mg/L [J. E. Turner et al.,J. Anal. Toxicol.,1977, 1, 103–104].
  • LD50 (rat)LD50=150 mg/kg
  • LD50 (mouse)N/A