- Molecular NameTolmetin
- SynonymTolmetin Sodium; Tolmetina [DCIT]; Tolmetine [INN-French]; Tolmetino [INN-Spanish]; Tolmetinum [INN-Latin]
- Weight257.289
- Drugbank_IDDB00500
- ACS_NO26171-23-3
- Show 2D model
- LogP (experiment)2.8
- LogP (predicted, AB/LogP v2.0)2.35
- pka3.5
- LogD (pH=7, predicted)-0.83
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.15
- LogSw (predicted, AB/LogsW2.0)0.43
- Sw (mg/ml) (predicted, ACD/Labs)0.77
- No.of HBond Donors1
- No.of HBond Acceptors4
- No.of Rotatable Bonds4
- TPSA59.3
- StatusFDA approved
- AdministrationN/A
- PharmacologyA non-steroidal anti-inflammatory drug of the arylalkanoic acids. It is used primarily to reduce hormones that cause pain, swelling, tenderness, and stiffness in conditions such as osteoarthritis and rheumatoid arthritis, including juvenile rheumatoid arthritis.
- Absorption_value99.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability95.0
- Protein binding99.6
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmEssentially all of the administered dose is recovered in the urine in 24 hours either as an inactive oxidative metabolite or as conjugates of tolmetin.
- Half life6 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.
- LD50 (rat)N/A
- LD50 (mouse)N/A