• Molecular NameThiamylal
  • SynonymNA
  • Weight254.354
  • Drugbank_IDDB01154
  • ACS_NO77-27-0
  • Show 3D model
  • LogP (experiment)3.23
  • LogP (predicted, AB/LogP v2.0)2.89
  • pka7.5
  • LogD (pH=7, predicted)2.77
  • Solubility (experiment)0.0531 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.2
  • LogSw (predicted, AB/LogsW2.0)0.18
  • Sw (mg/ml) (predicted, ACD/Labs)0.08
  • No.of HBond Donors2
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds5
  • TPSA90.29
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is used as a strong but short acting sedative. Thamylal is still in current use, primarily for induction in surgical anaesthesia or as an anticonvulsant to counteract side effects from other anaesthetics.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed (high lipid solubility).
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHeptatic
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)LD50=51 mg/kg (Intravenous)
  • LD50 (mouse)N/A