- Molecular NameMidodrine
- SynonymMidodrin; Midodrina [INN-Spanish]; Midodrine HCL; midodrine hydrochloride; Midodrinum [INN-Latin]
- Weight254.286
- Drugbank_IDDB00211
- ACS_NO133163-28-7
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)-0.86
- pka7.8
- LogD (pH=7, predicted)-1.77
- Solubility (experiment)Soluble
- LogS (predicted, ACD/Labs)(ph=7)0.02
- LogSw (predicted, AB/LogsW2.0)23.43
- Sw (mg/ml) (predicted, ACD/Labs)120.67
- No.of HBond Donors4
- No.of HBond Acceptors6
- No.of Rotatable Bonds6
- TPSA93.81
- StatusFDA approved
- AdministrationN/A
- PharmacologyA vasopressor/antihypotensive agent, it is an odorless, white, crystalline powder, soluble in water and sparingly soluble in methanol.
- Absorption_valueN/A
- Absorption (description)After oral administration, midodrine hydrochloride is rapidly absorbed.
- Caco_2N/A
- Bioavailability93.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThorough metabolic studies have not been conducted, but it appears that deglycination of midodrine to desglymidodrine takes place in many tissues, and both compounds are metabolized in party by the liver.
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose could include hypertension, piloerection (goosebumps), a sensation of coldness and urinary retention. The single doses that would be associated with symptoms of overdosage or would be potentially life- threatening are unknown.
- LD50 (rat)LD50=30~50 mg/kg
- LD50 (mouse)LD50=675 mg/kg