- Molecular NameKetoprofen
- Synonymm-Benzoylhydratropic acid
- Weight254.285
- Drugbank_IDDB01009
- ACS_NO22071-15-4
- Show 3D model
- LogP (experiment)3.12
- LogP (predicted, AB/LogP v2.0)2.94
- pka4.5
- LogD (pH=7, predicted)0.03
- Solubility (experiment)0.051 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.64
- LogSw (predicted, AB/LogsW2.0)0.14
- Sw (mg/ml) (predicted, ACD/Labs)0.15
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds4
- TPSA54.37
- StatusFDA approved
- AdministrationOral, topical, intravenous (veterinary use)
- PharmacologyOne of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects.
- Absorption_value95.0
- Absorption (description)Ketoprofen is readily absorbed after oral, rectal, or IM administration.
- Caco_2N/A
- Bioavailability85.0
- Protein binding95.0
- Volume of distribution (VD)0.1 to 0.2 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life1~4 h
- ExcretionAbout 75% of a single oral dose is excreted in the urine in 24 h, mostly in the first 6 h, about 90% of which is the glucuronide conjugate; hydroxylation may also occur.
- Urinary ExcretionN/A
- Clerance1~2 ml/min/kg
- ToxicityAdverse effects from overdose include breathing difficulty, coma, convulsions, drowsiness, high blood pressure, kidney failure, low blood pressure, nausea, sluggishness, stomach and intestinal bleeding, stomach pain, vomiting.
- LD50 (rat)LD50=62.4 mg/kg
- LD50 (mouse)N/A