• Molecular NameDexketoprofen
  • SynonymNA
  • Weight254.285
  • Drugbank_IDN/A
  • ACS_NO22161-81-5
  • Show 2D model
  • LogP (experiment)3.12
  • LogP (predicted, AB/LogP v2.0)2.94
  • pkaN/A
  • LogD (pH=7, predicted)0.03
  • Solubility (experiment)0.0507 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.64
  • LogSw (predicted, AB/LogsW2.0)0.14
  • Sw (mg/ml) (predicted, ACD/Labs)0.15
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds4
  • TPSA54.37
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA non-steroidal anti-inflammatory drug.
  • Absorption_valueN/A
  • Absorption (description)Dexketoprofen is rapidly absorbed
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding99.2
  • Volume of distribution (VD)0.25 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolised to produce an acyl-glucuronide conjugate metabolite, which is easily hydrolysed in plasma and alkali conditions.
  • Half life1.2~2.5 h
  • ExcretionThe drug is excreted in urine as the conjugate and also as the unaltered form when the glucuronide undergoes hydrolysis, so the metabolic transfer is reversed. Between 73 and 82% of a dose is recovered in urine within the first 12 h.
  • Urinary ExcretionN/A
  • Clerance0.10 L/kg/h
  • ToxicityGastro-intestinal toxicity can occur with potentially life threatening bleeding and perforations.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A