• Molecular NameDyphylline
  • SynonymDihydroxypropyl Theophylline; Dihydroxypropyl Theopylin; Diprofillin; Diprofilline; Diprophyllin; Diprophylline; Dipropylline; DT
  • Weight254.246
  • Drugbank_IDDB00651
  • ACS_NO479-18-5
  • Show 2D model
  • LogP (experiment)-1.46
  • LogP (predicted, AB/LogP v2.0)-0.97
  • pkaN/A
  • LogD (pH=7, predicted)-0.97
  • Solubility (experiment)300 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.19
  • LogSw (predicted, AB/LogsW2.0)159.99
  • Sw (mg/ml) (predicted, ACD/Labs)166.01
  • No.of HBond Donors2
  • No.of HBond Acceptors8
  • No.of Rotatable Bonds3
  • TPSA98.9
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA xanthine with broncho- and vasodilator properties.
  • Absorption_valueN/A
  • Absorption (description)Rapidly and almost completely absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability90.0
  • Protein binding84.0
  • Volume of distribution (VD)0.8 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life2 h
  • ExcretionAbout 83% of a dose is excreted in the urine as unchanged drug in 24 h; less than 1% of a dose is eliminated in the faeces. It is also rapidly absorbed from IM injection sites. Diprophylline is excreted in breast milk.
  • Urinary ExcretionN/A
  • Clerance5 ml/min/kg
  • ToxicityPlasma concentrations greater than 20 μg/mL may produce toxic effects.
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=1954 mg/kg