• Molecular NameNefopam
  • SynonymNA
  • Weight253.345
  • Drugbank_IDN/A
  • ACS_NO13669-70-0
  • Show 3D model
  • LogP (experiment)3.0
  • LogP (predicted, AB/LogP v2.0)3.2
  • pka9.2
  • LogD (pH=7, predicted)2.62
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.44
  • LogSw (predicted, AB/LogsW2.0)0.15
  • Sw (mg/ml) (predicted, ACD/Labs)0.76
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds1
  • TPSA12.47
  • StatusN/A
  • AdministrationOral, Intravenous
  • PharmacologyA centrally-acting but non-opioid analgesic drug of the benzoxazocine chemical class, developed in the early 1970s. It is widely used, mainly in European countries, for the relief of moderate to severe pain as an alternative to opioid analgesic drugs.
  • Absorption_value98.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability36.0
  • Protein binding75.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifePlasma half-life, 3 to 8 h (mean 4).
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A