• Molecular NameSulfamethoxazole
  • SynonymNA
  • Weight253.282
  • Drugbank_IDDB01015
  • ACS_NO723-46-6
  • Show 2D model
  • LogP (experiment)0.89
  • LogP (predicted, AB/LogP v2.0)1.03
  • pka5.6 (25°)
  • LogD (pH=7, predicted)-0.3
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.06
  • LogSw (predicted, AB/LogsW2.0)0.82
  • Sw (mg/ml) (predicted, ACD/Labs)0.3
  • No.of HBond Donors3
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds3
  • TPSA106.6
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA sulfonamide bacteriostatic antibiotic.
  • Absorption_value100.0
  • Absorption (description)Rapidly absorbed following oral administration.
  • Caco_2N/A
  • Bioavailability100.0
  • Protein binding62.0
  • Volume of distribution (VD)0.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic. The metabolism of sulfamethoxazole occurs predominately by N4-acetylation, although the glucuronide conjugate has been identified.
  • Half life10.1 h
  • ExcretionRenal
  • Urinary Excretion14
  • Clerance0.31 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A