• Molecular NameOxcarbazepine
  • SynonymOxcarbamazepine
  • Weight251.289
  • Drugbank_IDDB00776
  • ACS_NO28721-07-5
  • Show 3D model
  • LogP (experiment)1.807
  • LogP (predicted, AB/LogP v2.0)2.05
  • pkaN/A
  • LogD (pH=7, predicted)2.05
  • Solubility (experiment)0.308 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.39
  • LogSw (predicted, AB/LogsW2.0)0.1
  • Sw (mg/ml) (predicted, ACD/Labs)1.26
  • No.of HBond Donors3
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds0
  • TPSA70.18
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability95.0
  • Protein bindingN/A
  • Volume of distribution (VD)3.94 L/kg; monohydroxy derivative, 49 L
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmOxcarbazepine (O) undergoes extensive first-pass metabolism to an active metabolite, 10-hydroxycarbamazepine (HC). Reduction by cytosolic enzymes is stereoselective (80% S-enantiomer, 20% R-enantiomer), but both show similar pharmacological activity.
  • Half life2 h
  • ExcretionRenal
  • Urinary Excretion<1
  • Clerance67.4 ml/min/kg
  • ToxicityIsolated cases of overdose with oxcarbazepine have been reported. The maximum dose taken was approximately 24,000 mg. All patients recovered with symptomatic treatment.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A