- Molecular NameDiflunisal
- SynonymNA
- Weight250.2
- Drugbank_IDDB00861
- ACS_NO22494-42-4
- Show 2D model
- LogP (experiment)4.44
- LogP (predicted, AB/LogP v2.0)4.16
- pka3.3
- LogD (pH=7, predicted)0.3
- Solubility (experiment)Practically insoluble (14.5 mg/L) at neutral or acidic pH.
- LogS (predicted, ACD/Labs)(ph=7)-1.08
- LogSw (predicted, AB/LogsW2.0)0.02
- Sw (mg/ml) (predicted, ACD/Labs)0.2
- No.of HBond Donors2
- No.of HBond Acceptors3
- No.of Rotatable Bonds2
- TPSA57.53
- StatusFDA approved
- AdministrationN/A
- PharmacologyA generic NSAID (non-steroidal anti-inflammatory drug).
- Absorption_value100.0
- Absorption (description)Well absorbed after oral administration.
- Caco_2N/A
- Bioavailability85.0
- Protein binding99.9
- Volume of distribution (VD)0.1 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic, primarily via glucuronide conjugation (90% of administered dose). The only known metabolites in humans are Phase I1 products. It forms two types of glucuronides, a phenolic and an acyl glucuronide, and a sulfate conjugate. 3- Hydroxy-DF and 3-hydroxy-DF sulphate were also found to be minor metabolites of DF in humans.
- Half life5~12 h (dose-dependent)
- ExcretionUp to about 80% of a dose is excreted in the urine in 24 h, mostly as the ester and ether glucuronides. Less than 3% of a dose is eliminated in the faeces.
- Urinary ExcretionN/A
- Clerance0.1 ml/min/kg
- ToxicityDiflunisal appears to be relatively non-toxic. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams.
- LD50 (rat)392 mg/kg
- LD50 (mouse)439 mg/kg