• Molecular NamePyrimethamine
  • SynonymCD; Chloridin; Chloridine; Chloridyn; Diaminopyritamin; Ethylpyrimidine; Pirimetamin; Pirimetamina; Primethamine; Pyremethamine; Pyrimethamin; Pyrimethamine Hcl
  • Weight248.717
  • Drugbank_IDDB00205
  • ACS_NO58-14-0
  • Show 3D model
  • LogP (experiment)2.69
  • LogP (predicted, AB/LogP v2.0)2.74
  • pka7.3
  • LogD (pH=7, predicted)2.27
  • Solubility (experiment)0.121 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.23
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.06
  • No.of HBond Donors4
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds2
  • TPSA77.82
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention of malaria), and is also used (combined with sulfadiazine) in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals.
  • Absorption_value100.0
  • Absorption (description)Well absorbed with peak levels occurring between 2 to 6 hours following administration
  • Caco_2N/A
  • Bioavailability100.0
  • Protein binding90.0
  • Volume of distribution (VD)2.3 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life96 h
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A