• Molecular NamePindolol
  • SynonymBetapindol; Prinodolol
  • Weight248.326
  • Drugbank_IDDB00960
  • ACS_NO13523-86-9
  • Show 3D model
  • LogP (experiment)1.75
  • LogP (predicted, AB/LogP v2.0)1.96
  • pka8.8
  • LogD (pH=7, predicted)-0.44
  • Solubility (experiment)7.88 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)0.6
  • LogSw (predicted, AB/LogsW2.0)4.55
  • Sw (mg/ml) (predicted, ACD/Labs)4.18
  • No.of HBond Donors3
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds6
  • TPSA57.28
  • StatusFDA approved
  • AdministrationOral, IV
  • PharmacologyA beta blocker.
  • Absorption_value90.0
  • Absorption (description)Pindolol is rapidly and well absorbed from the GI tract.
  • Caco_2-4.78
  • Bioavailability88.0
  • Protein binding51.0
  • Volume of distribution (VD)1.2~3.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIt undergoes some first-pass-metabolization leading to an oral bioavailability of 50 to 95%. Patients with uremia may have a reduced bioavailability.
  • Half life2~4 h
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySigns of overdose include excessive bradycardia, cardiac failure, hypotension, and bronchospasm.
  • LD50 (rat)LD50=263 mg/kg
  • LD50 (mouse)N/A