• Molecular NameKetobemidone
  • SynonymNA
  • Weight247.338
  • Drugbank_IDN/A
  • ACS_NO469-79-4
  • Show 2D model
  • LogP (experiment)1.02
  • LogP (predicted, AB/LogP v2.0)1.16
  • pka8.7
  • LogD (pH=7, predicted)0.63
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.72
  • LogSw (predicted, AB/LogsW2.0)8.22
  • Sw (mg/ml) (predicted, ACD/Labs)10.98
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds3
  • TPSA40.54
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA powerful opioid analgesic. Its effectiveness against pain is in the same range as morphine, and it also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids.
  • Absorption_valueN/A
  • Absorption (description)Ketobemidone is poorly absorbed after oral or rectal administration.
  • Caco_2N/A
  • Bioavailability34.0
  • Protein binding99.0
  • Volume of distribution (VD)2 to 3 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIt is metabolised by N-demethylation.
  • Half life2 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • Clerance10 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A