- Molecular NameTinidazole
- Synonymtinidazole
- Weight247.275
- Drugbank_IDDB00911
- ACS_NO19387-91-8
- Show 3D model
- LogP (experiment)-0.35
- LogP (predicted, AB/LogP v2.0)-0.44
- pkaN/A
- LogD (pH=7, predicted)-0.44
- Solubility (experiment)19.9 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.83
- LogSw (predicted, AB/LogsW2.0)8.42
- Sw (mg/ml) (predicted, ACD/Labs)3.66
- No.of HBond Donors0
- No.of HBond Acceptors7
- No.of Rotatable Bonds5
- TPSA109.17
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn anti-parasitic drug used against protozoan infections.
- Absorption_value100.0
- Absorption (description)Rapidly and completely absorbed under fasting conditions. Administration with food results in a delay in Tmax of approximately 2 hours and a decline in Cmax of approximately 10% and an AUC of 901.6 ± 126.5 mcg hr/mL.
- Caco_2N/A
- Bioavailability98.0
- Protein binding12.0
- Volume of distribution (VD)0.7 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic, mainly via CYP3A4. Tinidazole, like metronidazole, is significantly metabolized in humans prior to excretion. Tinidazole is partly metabolized by oxidation, hydroxylation and conjugation. Tinidazole is the major drug-related constituent in plasma after human treatment, along with a small amount of the 2-hydroxymethyl metabolite.
- Half life12~17 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)LD50> 2,000 mg/kg
- LD50 (mouse)LD50>3,600 mg/kg