- Molecular NameBiotin
- Synonym(+)-Biotin; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid; cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid; Coenzyme R; D-Biotin; D(+)-Biotin; Vitamin B7; Vitamin H
- Weight244.315
- Drugbank_IDDB00121
- ACS_NO58-85-5
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)1.37
- pkaN/A
- LogD (pH=7, predicted)-0.76
- Solubility (experiment)0.22 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.11
- LogSw (predicted, AB/LogsW2.0)0.47
- Sw (mg/ml) (predicted, ACD/Labs)0.13
- No.of HBond Donors3
- No.of HBond Acceptors5
- No.of Rotatable Bonds5
- TPSA103.73
- StatusFDA approved
- AdministrationN/A
- PharmacologyA water-soluble B-complex vitamin which is composed of an ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme in the metabolism of fatty acids and leucine, and it plays a role in gluconeogenesis.
- Absorption_value100.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability99.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityAnimal studies have indicated few, if any, effects due to toxic doses of biotin. This may provide evidence that both animals and humans could tolerate doses of at least an order of magnitude greater than each of their nutritional requirements. There are no reported cases of adverse effects from receiving high doses of the vitamin, particularly when used in the treatment of metabolic disorders causing sebhorrheic dermatitis in infants.
- LD50 (rat)N/A
- LD50 (mouse)N/A