• Molecular NamePropranolol
  • SynonymDl-Propranolol Hydrochloride; Propanalol; Propanolol; Propranalol; propranolol; Propranolol Hcl; Propranolol Hydrochloride; R,S-Propranolol Hydrochloride
  • Weight243.35
  • Drugbank_IDDB00571
  • ACS_NO525-66-6
  • Show 3D model
  • LogP (experiment)3.09
  • LogP (predicted, AB/LogP v2.0)3.17
  • pka9.5
  • LogD (pH=7, predicted)0.69
  • Solubility (experiment)50.6 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.6
  • LogSw (predicted, AB/LogsW2.0)0.55
  • Sw (mg/ml) (predicted, ACD/Labs)0.36
  • No.of HBond Donors2
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds4
  • TPSA32.26
  • StatusFDA approved
  • AdministrationOral, IV
  • PharmacologyA non-selective beta blocker mainly used in the treatment of hypertension. It was the first successful beta blocker developed. It is the only drug proven effective for the prophylaxis of migraines in children.
  • Absorption_value95.0
  • Absorption (description)Propranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals.
  • Caco_2-4.58
  • Bioavailability26.0
  • Protein binding93.0
  • Volume of distribution (VD)4.3 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmCYP2D6 catalyzes the formation of 4-hydroxy metabolite; CYP1A2 is responsible for most of the N-desisopropyl metabolite; UGT catalyzes major conjugation pathway of elimination.
  • Half life3.9 h
  • Excretionrenal <1%
  • Urinary Excretion<0.5
  • Clerance16 ml/min/kg
  • ToxicitySymptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. LD50=565 mg/kg (orally in mice).
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=565 mg/kg