• Molecular NameClodronate
  • Synonymclodronate
  • Weight242.875
  • Drugbank_IDDB00720
  • ACS_NO10596-23-3
  • Show 3D model
  • LogP (experiment)-0.906
  • LogP (predicted, AB/LogP v2.0)-3.26
  • pkaN/A
  • LogD (pH=7, predicted)-9.86
  • Solubility (experiment)0.395 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)0.61
  • LogSw (predicted, AB/LogsW2.0)240.48
  • Sw (mg/ml) (predicted, ACD/Labs)101.55
  • No.of HBond Donors4
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds2
  • TPSA134.68
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA bisphosphonate. It is used in experimental medicine to selectively deplete for macrophages.
  • Absorption_value3.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability1.0
  • Protein binding19.0
  • Volume of distribution (VD)0.2 to 0.7 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmClodronate is not metabolized in humans.
  • Half life2 h; also reported as 5.6 h.
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A