• Molecular NameVancomycin
  • SynonymVancocin; Vancocin HCL; Vancoled; Vancor
  • Weight1449.27
  • Drugbank_IDDB00512
  • ACS_NO1404-90-6
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)N/A
  • pkaN/A
  • LogD (pH=7, predicted)N/A
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)N/A
  • LogSw (predicted, AB/LogsW2.0)N/A
  • Sw (mg/ml) (predicted, ACD/Labs)N/A
  • No.of HBond DonorsN/A
  • No.of HBond AcceptorsN/A
  • No.of Rotatable BondsN/A
  • TPSAN/A
  • StatusFDA approved
  • AdministrationIV, oral
  • PharmacologyA glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. It has traditionally been reserved as a drug of "last resort", used only after treatment with other antibiotics had failed, although the emergence of vancomycin-resistant organisms means that it is increasingly being displaced from this role by linezolid and daptomycin.
  • Absorption_value0.0
  • Absorption (description)Very poorly absorbed after oral administration, but used by this route to treat Clostridium difficile and staphylococcal enterocolitis.
  • Caco_2N/A
  • Bioavailability0.0
  • Protein binding30.0
  • Volume of distribution (VD)0.39 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmExcreted unchanged
  • Half life5.6 h
  • ExcretionRenal
  • Urinary Excretion79
  • Clerance0.79CLcr + 0.22
  • ToxicityThe oral LD50 in mice is 5000 mg/kg. The median lethal intravenous dose is 319 mg/kg in rats and 400 mg/kg in mice.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A