- Molecular NameThiopental
- SynonymPenthiobarbital; Pentothal; Pentothiobarbital; Thiomebumal; Thionembutal; Thiopentobarbital; Thiopentobarbitone; Thiopentobarbituric acid; Thiopentone; Tiopentale [Italian]
- Weight242.343
- Drugbank_IDDB00599
- ACS_NO76-75-5
- Show 3D model
- LogP (experiment)2.85
- LogP (predicted, AB/LogP v2.0)2.89
- pka7.6
- LogD (pH=7, predicted)2.77
- Solubility (experiment)0.106 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.06
- LogSw (predicted, AB/LogsW2.0)0.21
- Sw (mg/ml) (predicted, ACD/Labs)0.12
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds4
- TPSA90.29
- StatusFDA approved
- AdministrationOral, intravenous
- PharmacologyA rapid-onset short-acting barbiturate general anaesthetic. Sodium thiopental is a depressant and is sometimes used during interrogations—not to cause pain (in fact, it may have just the opposite effect), but to weaken the resolve of the subject and make him or her more compliant to pressure.
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding87.5
- Volume of distribution (VD)0.5~4 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmPrimarily hepatic. Biotransformation products of thiopental are pharmacologically inactive and mostly excreted in the urine.
- Half life9 h, increased after high doses (25 mg/min), up to 60 h.
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityOverdosage may occur from too rapid or repeated injections. Too rapid injection may be followed by an alarming fall in blood pressure even to shock levels. Apnea, occasional laryngospasm, coughing and other respiratory difficulties with excessive or too rapid injections may occur. Lethal blood levels may be as low as 1 mg/100 mL for short-acting barbiturates; less if other depressant drugs or alcohol are also present.
- LD50 (rat)N/A
- LD50 (mouse)N/A