- Molecular NameFenoprofen
- SynonymFeneprofen calcium salt dihydrate; Fenoprofen calcium; Fenoprofen calcium hydrate
- Weight242.274
- Drugbank_IDDB00573
- ACS_NO31879-05-7
- Show 3D model
- LogP (experiment)3.641
- LogP (predicted, AB/LogP v2.0)3.26
- pka4.5
- LogD (pH=7, predicted)0.54
- Solubility (experiment)Slightly soluble
- LogS (predicted, ACD/Labs)(ph=7)-1.1
- LogSw (predicted, AB/LogsW2.0)0.17
- Sw (mg/ml) (predicted, ACD/Labs)0.06
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds4
- TPSA46.53
- StatusFDA approved
- AdministrationN/A
- PharmacologyA non-steroidal anti-inflammatory drug.
- Absorption_value85.0
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- Bioavailability80.0
- Protein binding99.0
- Volume of distribution (VD)0.1 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMajor urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
- Half life2~3 h
- ExcretionAbout 90% of a dose is excreted in the urine in 24 h, about 3% of the excreted material being unchanged drug, about 45% fenoprofen glucuronide, about 42% 4-hydroxyfenoprofen glucuronide and about 2% free 4-hydroxyfenoprofen. About 2% of a dose is eliminated in the faeces in 24 h.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose appear within several hours and generally involve the gastrointestinal and central nervous systems. They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion. Hyperpyrexia, tachycardia, hypotension, and acute renal failure may occur rarely following overdose. Respiratory depression and metabolic acidosis have also been reported following overdose with certain NSAIDs. Recovery has been reported after the ingestion of about 60 g.
- LD50 (rat)N/A
- LD50 (mouse)N/A