- Molecular NameMefenamic acid
- SynonymAcide Mefenamique; Mefanamic Acid; Mefenacid; Mefenaminsaeure; Mephenamic Acid; Mephenaminic Acid; Methenamic Acid
- Weight241.29
- Drugbank_IDDB00784
- ACS_NO61-68-7
- Show 2D model
- LogP (experiment)5.12
- LogP (predicted, AB/LogP v2.0)4.94
- pka4.2
- LogD (pH=7, predicted)2.25
- Solubility (experiment)0.02 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.54
- LogSw (predicted, AB/LogsW2.0)0.04
- Sw (mg/ml) (predicted, ACD/Labs)0.03
- No.of HBond Donors2
- No.of HBond Acceptors3
- No.of Rotatable Bonds3
- TPSA49.33
- StatusFDA approved
- AdministrationN/A
- PharmacologyA non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration.
- Absorption_value90.0
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- Bioavailability90.0
- Protein binding99.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic (CYP2C9). Metabolised by hydroxylation of the 3′-methyl group followed by oxidation to produce the 3′-carboxy metabolite; glucuronide conjugation also occurs.
- Half life2~4 h
- ExcretionAbout 52% of a dose is excreted in the urine in 48 h, 6% as mefenamic acid and the other 46% as conjugated metabolites; about 20% of a dose is eliminated in the faeces, mostly as unconjugated 3′-carboxymefenamic acid. Trace amounts of mefenamic acid may be present in breast milk.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityToxic effects are usually associated with plasma concentrations greater than 10 g/L.
- LD50 (rat)LD50=740 mg/kg
- LD50 (mouse)LD50=2000