• Molecular NameTetrahydrobiopterin
  • Synonym5,6,7,8 Tetrahydrobiopterin; BH4; sapropterin
  • Weight241.251
  • Drugbank_IDDB00360
  • ACS_NO17528-72-2
  • Show 3D model
  • LogP (experiment)-1.783
  • LogP (predicted, AB/LogP v2.0)-3.07
  • pkaN/A
  • LogD (pH=7, predicted)-3.08
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.62
  • LogSw (predicted, AB/LogsW2.0)2.16
  • Sw (mg/ml) (predicted, ACD/Labs)301.75
  • No.of HBond Donors7
  • No.of HBond Acceptors8
  • No.of Rotatable Bonds2
  • TPSA132.0
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA naturally occurring nutrient and essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine (5-HT)), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and nitric oxide (NO).
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A