• Molecular NamePentolinium
  • SynonymPentolinium tartrate; Pentolonium; Pentolonum
  • Weight240.435
  • Drugbank_IDDB01090
  • ACS_NO52-62-0
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)-5.17
  • pkaN/A
  • LogD (pH=7, predicted)-5.17
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.07
  • LogSw (predicted, AB/LogsW2.0)325154.0
  • Sw (mg/ml) (predicted, ACD/Labs)279.5
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds6
  • TPSA0.0
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyPentolinium acts as a ganglionic blocking agent. Pentolinium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)LD50=890 mg/kg
  • LD50 (mouse)LD50=512 mg/kg