- Molecular NameBenzphetamine
- SynonymBenzfetamine; Benzphetamine Hydrochloride; Benzylamphetamine
- Weight239.362
- Drugbank_IDDB00865
- ACS_NO156-08-1
- Show 3D model
- LogP (experiment)4.374
- LogP (predicted, AB/LogP v2.0)4.36
- pka7.6
- LogD (pH=7, predicted)4.24
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-1.62
- LogSw (predicted, AB/LogsW2.0)0.05
- Sw (mg/ml) (predicted, ACD/Labs)0.09
- No.of HBond Donors0
- No.of HBond Acceptors1
- No.of Rotatable Bonds5
- TPSA3.24
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn anorectic drug marketed under this brand in the USA by Pharmacia. Benzphetamine is used as a short term adjunct in management of exogenous obesity. It is closely related to amphetamine.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding87.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmBenzphetamine is metabolized by the human body into amphetamine and methamphetamine metabolites, making it one of the very few drugs to undergo in vivo conversion to a substance of higher addiction and abuse potential.
- Half life16~31 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityLD50=160 mg/kg (orally in rats). Acute overdosage may result in restlessness, tremor, tachypnea, confusion, assaultiveness, and panic states.
- LD50 (rat)N/A
- LD50 (mouse)N/A