• Molecular NameProcaine
  • Synonymprocaine HCl
  • Weight236.315
  • Drugbank_IDDB00721
  • ACS_NO59-46-1
  • Show 3D model
  • LogP (experiment)1.87
  • LogP (predicted, AB/LogP v2.0)2.07
  • pka9.0
  • LogD (pH=7, predicted)0.25
  • Solubility (experiment)4.11 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.02
  • LogSw (predicted, AB/LogsW2.0)5.92
  • Sw (mg/ml) (predicted, ACD/Labs)1.5
  • No.of HBond Donors2
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds7
  • TPSA55.56
  • StatusFDA approved
  • AdministrationParenteral
  • PharmacologyA local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, procaine is sometimes referred to generically as novocaine. It acts mainly by being a sodium channel blocker.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability0.0
  • Protein binding6.0
  • Volume of distribution (VD)0.79 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHydrolysis by plasma esterases
  • Half life0.1 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=222 (Intravenous)