• Molecular NameThioacetazone
  • SynonymNA
  • Weight236.299
  • Drugbank_IDN/A
  • ACS_NO104-06-3
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)1.41
  • pkaN/A
  • LogD (pH=7, predicted)1.41
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)-3.43
  • LogSw (predicted, AB/LogsW2.0)0.11
  • Sw (mg/ml) (predicted, ACD/Labs)0.09
  • No.of HBond Donors4
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds4
  • TPSA111.6
  • StatusN/A
  • AdministrationN/A
  • PharmacologyThioacetazone is used in the treatment of tuberculosis; it has only weak activity against Mycobacterium tuberculosis and is only useful in preventing resistance to more powerful drugs like isoniazid and rifampicin. It is never used on its own to treat tuberculosis; it is used in a similar way to ethambutol. Thioacetazone is the only anti-TB drug that is ineffective when given intermittently.
  • Absorption_value20.0
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding95.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A