- Molecular NameCyclobarbital
- SynonymNA
- Weight236.271
- Drugbank_IDN/A
- ACS_NO52-31-3
- Show 3D model
- LogP (experiment)1.77
- LogP (predicted, AB/LogP v2.0)1.74
- pka7.6
- LogD (pH=7, predicted)1.69
- Solubility (experiment)2.26 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.55
- LogSw (predicted, AB/LogsW2.0)0.85
- Sw (mg/ml) (predicted, ACD/Labs)0.61
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds2
- TPSA75.27
- StatusN/A
- AdministrationN/A
- PharmacologyA drug which is a barbiturate derivative.
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding70.0
- Volume of distribution (VD)0.5 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe main metabolic reaction appears to be oxidation to ketocyclobarbital [5-(3-oxocyclohex-1-enyl)-5-ethylbarbituric acid].
- Half life12 h
- ExcretionLess than 10% of a dose is excreted in the urine unchanged.
- Urinary ExcretionN/A
- Clerance0.5 ml/min/kg
- ToxicityThe estimated minimum lethal dose is 2 g. Severe toxic effects are associated with blood concentrations greater than 10 mg/L.
- LD50 (rat)N/A
- LD50 (mouse)N/A