- Molecular NameIsosorbide_dinitrate
- SynonymDianhydrosorbitol 2,5-dinitrate; Sorbide nitrate; Sorbide, dinitrate; Sorbidnitrate
- Weight236.136
- Drugbank_IDDB00883
- ACS_NO87-33-2
- Show 3D model
- LogP (experiment)1.31
- LogP (predicted, AB/LogP v2.0)1.54
- pkaN/A
- LogD (pH=7, predicted)1.54
- Solubility (experiment)1.089 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.82
- LogSw (predicted, AB/LogsW2.0)0.35
- Sw (mg/ml) (predicted, ACD/Labs)3.59
- No.of HBond Donors0
- No.of HBond Acceptors10
- No.of Rotatable Bonds4
- TPSA134.58
- StatusFDA approved
- AdministrationN/A
- PharmacologyA nitrate used pharmacologically as a vasodilator, e.g. in angina pectoris but also for anal fissure, a condition which is known to involve decreased blood supply leading to poor healing. It is also used as a direct vasodilator to treat congestive heart failure.
- Absorption_value90.0
- Absorption (description)Isosorbide dinitrate is readily absorbed after sublingual or oral administration.
- Caco_2N/A
- Bioavailability22.0
- Protein binding28.0
- Volume of distribution (VD)3.1 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is metabolised by enzymatic denitration followed by glucuronide conjugation. Isosorbide 2-mononitrate and isosorbide 5-mononitrate have some pharmacological activity.
- Half life0.7 h
- ExcretionAbout 80% of a dose is excreted in the urine in 24 h, of which about 50% is isosorbide glucuronide, up to 15% is free and conjugated isosorbide 5-mononitrate, about 1% is free isosorbide 2-mononitrate, and less than 1% is unchanged drug.
- Urinary Excretion<1
- Clerance46 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A