- Molecular NameProcainamide
- SynonymNA
- Weight235.331
- Drugbank_IDDB01035
- ACS_NO51-06-9
- Show 3D model
- LogP (experiment)0.88
- LogP (predicted, AB/LogP v2.0)1.05
- pka9.2
- LogD (pH=7, predicted)-1.15
- Solubility (experiment)5.05 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.63
- LogSw (predicted, AB/LogsW2.0)19.99
- Sw (mg/ml) (predicted, ACD/Labs)7.58
- No.of HBond Donors3
- No.of HBond Acceptors4
- No.of Rotatable Bonds6
- TPSA58.36
- StatusFDA approved
- AdministrationIV, IM, oral
- PharmacologyA pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias, classified by the Vaughan Williams classification system as class Ia.
- Absorption_value85.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability83.0
- Protein binding16.0
- Volume of distribution (VD)1.9 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic (CYP2D6-mediated)
- Half life3 h
- ExcretionRenal
- Urinary Excretion67
- CleranceCL = 2.7CLcr + 1.7 + 3.2 (fast) or + 1.1 (slow)
- ToxicityLD50=95 mg/kg (rat, IV); LD50=312 mg/kg (mouse, oral); LD50=103 mg/kg (mouse, IV); LD50=250 mg/kg (rabbit, IV)
- LD50 (rat)LD50=95 mg/kg (IV)
- LD50 (mouse)LD50=312 mg/kg (mouse, oral); LD50=103 mg/kg (mouse, IV);