- Molecular NameMeptazinol
- SynonymNA
- Weight233.355
- Drugbank_IDN/A
- ACS_NO54340-58-8
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)3.76
- pkapKa8.7 (-NH2), 11.9 (phenol)
- LogD (pH=7, predicted)1.32
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.06
- LogSw (predicted, AB/LogsW2.0)0.5
- Sw (mg/ml) (predicted, ACD/Labs)2.54
- No.of HBond Donors1
- No.of HBond Acceptors2
- No.of Rotatable Bonds2
- TPSA23.47
- StatusN/A
- AdministrationOral, IM, IV
- PharmacologyAn opioid analgesic for use with moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth).
- Absorption_value100.0
- Absorption (description)Readily and almost completely absorbed after oral administration. Rapidly absorbed after intramuscular or rectal administration.
- Caco_2N/A
- Bioavailability9.0
- Protein binding27.0
- Volume of distribution (VD)5 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe drug is rapidly metabolised to the glucuronide
- Half life2 h
- ExcretionIt is excreted rapidly in the urine, mainly as the glucuronide conjugate, with less than 5% of a dose as unchanged drug, and about 5 to 10% as 7-oxomeptazinol. Both metabolites are inactive. Over 50% of a dose is excreted in the urine in 9 h and over 60% in 24 h. Less than 10% of an oral dose is eliminated in the faeces.
- Urinary ExcretionN/A
- Clerance30 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A