- Molecular NameSulbactam
- SynonymNA
- Weight233.244
- Drugbank_IDN/A
- ACS_NO68373-14-8
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)-0.93
- pkaN/A
- LogD (pH=7, predicted)-4.91
- Solubility (experiment)Soluble
- LogS (predicted, ACD/Labs)(ph=7)0.63
- LogSw (predicted, AB/LogsW2.0)246.18
- Sw (mg/ml) (predicted, ACD/Labs)3.83
- No.of HBond Donors1
- No.of HBond Acceptors6
- No.of Rotatable Bonds1
- TPSA100.13
- StatusN/A
- AdministrationInjection
- PharmacologyA molecule which is given in combination with beta-lactam antibiotics to inhibit beta-lactamase, an enzyme produced by bacteria that destroys the antibiotics.
- Absorption_value5.0
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding38.0
- Volume of distribution (VD)0.34 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life1 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe most frequently reported systemic adverse reactions were diarrhea in 3% of the patients and rash in less than 2% of the patients. Additional reactions reported in less than 1% of the patients were: itching, nausea, vomiting, candidiasis, fatigue, malaise, headache, chest pain, flatulence, abdominal distension, glossitis, urine retention, dysuria, edema, facial swelling, erythema, chills, tightness in throat, substernal pain, epistaxis and mucosal bleeding. Local adverse reactions include pain at IM injection site (16%), pain at IV injection site (3%), thrombophlebitis (3%)
- LD50 (rat)N/A
- LD50 (mouse)N/A