• Molecular NamePhenobarbital
  • SynonymFenobarbital; Phenobarbitol; Phenobarbitone; Phenobarbituric Acid; Phenylethylbarbiturate; Phenylethylbarbituric Acid; Phenylethylmalonylurea
  • Weight232.239
  • Drugbank_IDDB01174
  • ACS_NO50-06-6
  • Show 2D model
  • LogP (experiment)1.47
  • LogP (predicted, AB/LogP v2.0)1.4
  • pka7.4 (25°)
  • LogD (pH=7, predicted)1.28
  • Solubility (experiment)1.1 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.5
  • LogSw (predicted, AB/LogsW2.0)0.47
  • Sw (mg/ml) (predicted, ACD/Labs)0.58
  • No.of HBond Donors2
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds2
  • TPSA75.27
  • StatusFDA approved
  • AdministrationOral, rectal, parenteral (intramuscular and intravenous)
  • PharmacologyThe most widely used anticonvulsant worldwide and the oldest still commonly used.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability94.0
  • Protein binding51.0
  • Volume of distribution (VD)0.54 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (mostly CYP2C19)
  • Half life53 to 118 hours (mean 79 hours)
  • ExcretionRenal and fecal
  • Urinary Excretion24
  • Clerance0.062 ml/min/kg
  • ToxicityCNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=168